Global Guts, featuring competitors from various countries, namely the United States of America (USA), Mexico, Great Britain, Israel, Germany, Spain, Portugal, and the Commonwealth of Independent States.

Although the countries had multiple contestants, no country was ever represented twice in a single episode, except for the Special Olympic special, where it had 2 U.S. players.

Each country had its own team of broadcasters; e.g. O'Malley retained this role for the US broadcast. The format remained identical to the original version, but the Mega Crag was upgraded to the Super Aggro Crag. In the "Spill Your GUTS" segments, non-English-speaking contestants spoke in their own language, with an interpreter speaking over their lines.